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poliovirus receptor-related 3 creativebiomart.net
Nectins originally identified as poliovirus receptor-related protein (PRR) are Ca2+-independent immunoglobulin-like cell-cell-adhesion molecules. Nectins comprise a family of four members: nectin-1 (CD111/PRR1), nectin-2 (CD112/PRR2), nectin-3 (CD113/PRR3
SynonymsPVRL3; poliovirus receptor-related 3; poliovirus receptor-related protein 3; CD113; CDw113; DKFZP566B0846; nectin 3; PPR3; PVRR3; PRR3; NECTIN-3; FLJ90624
protein tyrosine phosphatase, receptor type, N creativebiomart.net
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
paraspeckle component 1 creativebiomart.net
This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified.
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 creativebiomart.net
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes;the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap;complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on;the long arm of chromosome 2.
SynonymsPSMD14; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; 26S proteasome non-ATPase regulatory subunit 14; pad1; POH1; Rpn11; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated PAD1 homolog 1
prostate stem cell antigen creativebiomart.net
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.
protease, serine, 8 creativebiomart.net
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.
SynonymsPRSS8; protease, serine, 8; prostasin; AI313909; 2410039E18Rik; C79772; CAP1; Channel Activating Protease 1; mCAP1; Prostasin heavy chain; PRSS8_HUMAN; Serine protease 8; channel-activating protease 1
protease, serine, 2 (trypsin 2) creativebiomart.net
Trypsinogen is the precursor form or zymogen of the pancreatic enzyme trypsin. It is found in pancreatic juice, along with amylase, lipase, and chymotrypsinogen. It is activated by enteropeptidase, which is found in the intestinal mucosa, to form trypsin. Once activated, the trypsin can activate more trypsinogen into trypsin. Trypsin cleaves peptide bond on carboxyl side of basic amino acids. Serum trypsinogen is measured using a blood test. High levels are seen in acute pancreatitis, and cystic fibrosis.
SynonymsPRSS2 protease, serine, 2; PRSS2; TRYP; 8 anionic trypsin; pancreatic anionic trypsinogen; NP_777115.1; EC 3.4.21.4; Trypsinogen
protein S (alpha) creativebiomart.net
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]
SynonymsPROS1; protein S (alpha); PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; vitamin K-dependent protein S; protein Sa; vitamin K-dependent plasma protein S;
neurofilament, light polypeptide creativebiomart.net
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains.;Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role;in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations;in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous;system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
neutral cholesterol ester hydrolase 1 creativebiomart.net
NCEH1 involved in several pathways and played different roles in them. We selected most pathways NCEH1 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCEH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.