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eukaryotic translation initiation factor 3, subunit M creativebiomart.net
This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required;for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the;encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of;mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome.
eukaryotic translation initiation factor 2-alpha kinase 2 creativebiomart.net
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
SynonymsEIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; PKR; PRKR; EIF2AK1; interferon-induced, double-stranded RNA-activated protein kinase; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein kinase, interferon-inducible double stranded RNA
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