MSRA carries out the enzymatic reduction of methionine-S-sulfoxide (MetSO) to methionine in thioredoxin-dependent manner. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its proposed function is the repair of oxidative damage to proteins to restore biological activity. The two known splice variants of the mammalian protein are located in mitochondria and the cytosol, respectively. In addition is revealed a MSRA-immunoreactivity into the nuclei of endo-and- myometrium cells oft he human uterus.
SynonymsMSRA; methionine sulfoxide reductase A; mitochondrial peptide methionine sulfoxide reductase; peptide Met(O) reductase; peptide met (O) reductase; protein-methionine-S-oxide reductase; peptide methionine sulfoxide reductase; peptide-methionine (S)-S-oxide reductase; cytosolic methionine-S-sulfoxide reductase; PMSR;